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Anti-diabetic potential of Pueraria lobata root extract through promoting insulin signaling by PTP1B inhibition.

Ran Sun,Xinxian Deng,Dongdong Zhang,Fangzhou Xie,Di Wang,Juntao Wang,Mojdeh S Tavallaie,Faqin Jiang,Lei Fu

Bioorganic Chemistry（2019）

Cited 23|Views20
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Abstract
•P. lobata exhibited higher PTP1B inhibitory activity compared to that of TCPTP, SHP-2 and DPP-4.•P. lobata increased the glucose uptake by two times in HepG2 cells.•20% decreased blood glucose (AUC) was obtained in T2DM mice treated with P. lobata.
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Key words
Pueraria lobata,T2DM,Anti-diabetic activities,PTP1B
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