Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Jing Fang,Lyndsey C Bolanos,Kwangmin Choi,Xiaona Liu,Susanne Christie,Shailaja Akunuru,Rupali Kumar,Dehua Wang,Xiaoting Chen,Kenneth D Greis,Peter Stoilov,Marie-Dominique Filippi,Jaroslaw P Maciejewski,Guillermo Garcia-Manero,Matthew T Weirauch,Nathan Salomonis,Hartmut Geiger,Yi Zheng,Daniel T Starczynowski

Nature Immunology（2016）

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摘要

Starczynowski and colleagues show that overexpression of TRAF6 in HSCs induces ubiquitination of the RNA-binding protein hnRNPA1 and alternative splicing of Arhgap1, which accounts for the hematopoietic defects in myelodysplastic syndromes.

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关键词

Leukaemia,Toll-like receptors,Biomedicine,general,Immunology,Infectious Diseases

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