Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: Outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and F-FDG-PET/CT.

•Larynx preservation (LP) in advanced larynx/hypopharynx squamous cell carcinoma (LHSCC) features uncertainties.•After 1 cycle induction chemotherapy (IC-1) endoscopic response assessment of tumour surface shrinkage (ETSS) is recommended.•This is the largest study in advanced LHSCC comparing ETSS, CT-volumetry and PET/CT after IC-1 in a prospective LP trial.•Hazard ratios of 4 independent predictors define a new score for laryngectomy-free survival (LFS), the LFS-score.•Responders with ETSS ≥ 30% and LFS-score ≤16 achieve prolonged LFS, tumour-specific and overall survival.