LC-ESI-MS/MS evaluation of forced degradation behaviour of silodosin: In vitro anti cancer activity evaluation of silodosin and major degradation products.

Chiguru Vishnuvardhan,Baikadi Saibaba,Lingesh Allakonda,Debasish Swain,S Gananadhamu,R Srinivas,N Satheeshkumar

Journal of Pharmaceutical and Biomedical Analysis（2017）

引用 11|浏览3

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摘要

•Forced degradation studies of silodosin under hydrolytic (acidic, alkaline and neutral), oxidation, photolysis and thermal stress conditions.•Isolation of major degradation products (DP 1 and DP 2).•Identification of 5 hitherto unknown DPs by LC–ESI–MS/MS experiments.•In vitro anticancer activity studies on silodosin, DP 1 and DP 2 using PC 3 cells by MTT assay.

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关键词

Forced degradation,LC–MS/MS,Isolation of DPs,Anti cancer activity,MTT assay

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