Inhibition of siglec-1 by lentivirus mediated small interfering RNA attenuates atherogenesis in apoE-deficient mice.

Yi-song Xiong,Ai-lin Wu,Dong Mu,Juan Yu,Ping Zeng,Yi Sun, Jie Xiong

Clinical Immunology（2017）

引用 12|浏览6

暂无评分

摘要

•Siglec-1 in AS plaques can be suppressed by Lv-shSiglec-1 in vitro and in vivo.•Blockade of Siglec-1 prevents AS lesion formation in Apoe−/− mice.•Inhibition of Siglec-1 decreases monocytes adhesion to aortic wall.•Blockage of Siglec-1 diminishes peritoneal macrophages internalization of oxLDL.

查看译文

关键词

Atherosclerosis,Cell adhesion molecules,Gene therapy,Inflammation

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要