Selective Mineralization of Tough Hydrogel Lumens for Simulating Arterial Plaque

This paper demonstrates progress of fabricating artificial arteries (phantoms) that mimic plaque buildup. Hydrogel lumens are molded using tough polyacrylamide with regions selectively mineralized with calcium phosphate. By tuning the degree of mineralization such as calcium concentration ([Ca2+ ], 0.4-2 M), and crystallization time (t(c), 1-4 weeks), the authors control the extent of lumen occlusion. These occluded lumens significantly reduce pressure (Delta p approximate to 7.79 kPa) during fluid flow compared to the non-calcified lumens (Delta P approximate to 1.24 kPa). Additionally, image, chemical analysis, and compressive mechanical tests are performed to determine the effect of synthesis conditions on the composite's mechanical properties. For comparison to real arteries, the authors also present dynamic mechanical analysis of human aortic tissue.