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Combination of RNA- and exome sequencing: Increasing specificity for identification of somatic point mutations and indels in acute leukaemia.

Marcus Celik Hansen,Laura Laine Herborg,Maria Hansen,Anne Stidsholt Roug,Peter Hokland

Leukemia Research（2016）

Cited 3|Views19
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Abstract
•A method for improved detection of somatic mutations in acute leukemia is proposed.•The workflow involves combination of whole exome and RNA-sequencing.•Noise is reduced and it enables objective evaluation of possible driver mutations.
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Key words
RNA-sequencing,Exome sequencing,Next generation sequencing,Somatic mutations,Acute myeloid leukemia
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