Combination of RNA- and exome sequencing: Increasing specificity for identification of somatic point mutations and indels in acute leukaemia.
Leukemia Research(2016)
Abstract
•A method for improved detection of somatic mutations in acute leukemia is proposed.•The workflow involves combination of whole exome and RNA-sequencing.•Noise is reduced and it enables objective evaluation of possible driver mutations.
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Key words
RNA-sequencing,Exome sequencing,Next generation sequencing,Somatic mutations,Acute myeloid leukemia
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