Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.

Pavlína Hašková,Hana Jansová,Jan Bureš,Miloslav Macháček,Anna Jirkovská,Katherine J Franz,Petra Kovaříková,Tomáš Šimůnek

Toxicology（2016）

Cited 16|Views11

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Abstract

•Fe prochelator BHAPI was examined for protection against catecholamine cardiotoxity.•BHAPI has no affinity for iron ions until it is activated to active chelator HAPI.•Catecholamines, as a source of ROS, induced conversion of BHAPI into HAPI.•BHAPI and HAPI decrease ROS formation induced by catecholamines.•BHAPI and HAPI protect H9c2 cells against oxidative injury induced by catecholamines.

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Key words

ACN,BHAPI,CA,CHEL,DCF,DMSO,EC50 value,EPI,FAC,FAS,FBS,Fe,GSH,GSSG,H2DCF-DA,HAPI,ISO,oxCA,oxEPI,oxISO,PI,proCHEL,ROS,SIH,t1/2 values,TC50 values

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