A New Aromatase Inhibitor, FR901537

Nobutaka Oohata,Yasuhiro Hori,Yukiko Yamagishi,Takashi Fujita,Shigehiro Takase,Michio Yamashita,Hiroshi Terano,Masakuni Okuhara

JOURNAL OF ANTIBIOTICS（1995）

Cited 5|Views23

No score

Abstract

FR901537 is a new aromatase inhibitor produced by a bacterium Bacillus sp. No. 3072. Structural studies of FR901537 suggested that it was a novel naphthol derivative having pantetheine in its structure. FR901537 showed a potent inhibitory activity against aromatase from human placenta or rat ovary, but did not inhibit the activity of 11 beta-hydroxylase from bovine adrenal cortex. Lineweaver-Burk plot analysis revealed that FR901537 is a competitive inhibitor.

Translated text

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined