Long-Term Outcomes Of Cytoreduction And Hipec For Malignant Peritoneal Mesothelioma

4111 Background: The prognosis of malignant peritoneal mesothelioma (MPM) has improved over the past decade in patients undergoing operative extirpation and intraperitoneal chemotherapy (IC). This study investigates the largest reported cohort of patients operated on for MPM. Methods: Kaplan-Meier curves and univariate cox proportional hazards model was used to estimate survival and significant treatment and prognosis factors, for 195 patients who underwent cytoreductive surgery and or HIPEC treatment between 1995-2014; patients were not excluded for bicavity disease or for unresectable disease. Results: The median survival time was 3.21 years with (95% CI: 2.38- 5.53), with median follow-up of 3.44 years (SD = 3.4, minimum = 0.014 and maximum = 16.752) years from first operation. The mean age at diagnosis was 54.8 years [HR: 1.027 (95% CI: 1.012-1.042)] with 111 men (57%) and 84 women (43.1), with female gender having favorable survival [HR: 0.442 95% CI: 0.296-0.659)]. Asbestos exposure was reported in ...