Effect Of Asiatic Acid On The Treatment Of Spinal Cord Injury: An Experimental Study In Rats
TURKISH NEUROSURGERY(2017)
Abstract
AIM: Spinal cord injury (SCI) is a devastating condition of the central nervous system. There is no proven therapeutic agent for the treatment of this complex disorder. Asiatic acid (AA) has been used as an anti-inflammatory and anti-oxidant agent in Eastern countries for many years. The aim of this study was to investigate the effectiveness of AA on the treatment of traumatic SCI in rats.MATERIAL and METHODS: Thirty-two adult male Sprague-Dawley rats were divided into 4 groups as laminectomy, laminectomy+trauma, vehicle, and M treatment groups. SCI was created by the modified Allen's weight-drop technique. After the injury, the levels of pro-inflammatory cytokines (IL-6, IL-beta, TNF-alpha) and lipid peroxidation products (MDA) were measured. Tarlov functional recovery scores were also determined for each rat. The One-way ANOVA test was used for the analysis of difference between 4 experimental groups and the groups were compared individually by Tukey-LSD post hoc analysis test (p=0.001).RESULTS: AA administration just after SCI attenuated the levels of lipid peroxidation products (MDA) and pro-inflammatory cytokines (TNF-alpha,IL1 beta). It also increased the Tarlov functional recovery scores of the rats.CONCLUSION: AA administration could attenuate a number of deleterious reactions after traumatic SCI. Further studies are needed to elucidate the pathways of neuroprotective effects of AA after spinal trauma.
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Key words
Asiatic acid,Spinal cord injury,Trauma
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