Self-assembly and drug release study of linear l,d-oligopeptide-poly(ethylene glycol) conjugates.

New Biotechnology(2017)

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摘要
•Synthesis of pegylated regular alternating l,d tetra and hexapeptide is reported.•Structures of pegylated regular alternating l,d tetra and hexapeptide is reported.•The self-assembling capability was assessed by DLS, SEM, CD, fluorescence, NMR.•The self-assembling properties depend significantly on the length of the peptide.•The drug loading end release capacity of the model drug curcumin was investigated.
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关键词
Linear l,d-peptide,Poly(ethylene glycol),Conjugated l,d-peptide-polymer,Self-assembly,Nanoparticles,Drug loading,Sustained release
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