Mutating Heme Oxygenase-1 Into A Peroxidase Causes A Defect In Bilirubin Synthesis Associated With Microcytic Anemia And Severe Hyperinflammation

Johann Greil,Maria V. Verga-Falzacappa,Nicole E. Echner,Wolfgang Behnisch,Obul R. Bandapalli,Paulina Pechanska,Stephan Immenschuh,Vijith Vijayan,Jozsef Balla, Hirokatsu Tsukahara,Marion Schneider,Gritta Janka,Maren Claus,Thomas Longerich,Martina U. Muckenthaler,Andreas E. Kulozik

HAEMATOLOGICA（2016）

Cited 15|Views36

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Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder characterized by fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypercytokinemia, and hemophagocytosis. The genetically determined forms of HLH, also referred to as familial hemophagocytic lymphohistiocytosis,

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