Higher Leukemia Free Survival After Post-Induction Hematopoietic Cell Transplantation Compared To Consolidation Therapy In Patients > 60 Years With Acute Myelogenous Leukemia (Aml): Report From The Aml 2004 East German Study Group (Osho)

Treatment of elderly patients with AML remains challenging. While increasing doses of induction and consolidation chemotherapy have failed to improve outcome, efforts to decrease relapse rates using the graft-versus-leukemia effect have shown promising results in phase II studies. In the present analysis of the prospective OSHO 2004 study we evaluated the effect of post-induction hematopoietic cell transplantation (HCT) in comparison to conventional consolidation chemotherapy (CT) on outcome in elderly patients with AML.