Costimulation Blockade with CD40mAb in (Life-Supporting) Heterotopic and Orthotopic Cardiac Xenotransplantation of GalT-KO/hCD46/hTM Transgenic Pig Hearts in a Pig-to-Baboon Model

P. Brenner,Tanja Mayr,Sonja Guethoff,Stefan Buchholz, T. Pöttinger, I. Lutzmann,Fabian Werner,Andreas Bauer,Nikolai Klymiuk,Eckhard Wolf,Keith A. Reimann,Muhammad M. Mohiuddin,W. Hermanns,D. Ayares,C. McGregor, J. Lambris, Christian Hagl,Bruno Reichart,Jan-Michael Abicht

Thoracic and Cardiovascular Surgeon（2016）

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摘要

Aim: To verify and reproduce the excellent > 2 years long-term survival of the heterotopic, nonlife-supporting abdominal heart xenotransplantation (AHHXTx) model of Mohiuddin's group with a recombinant mouse-rhesus chimeric CD40 antibody (clone 2C10R4) this costimulation blockade was used in the life-supporting thoracic heterotopic (THHXTx) and orthotopic (OHXTx) heart transplant models.

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galt-ko/hcd46/htm transgenic pig hearts,orthotopic cardiac xenotransplantation,life-supporting,pig-to-baboon

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