ELISA units, IgG subclass ratio and avidity determined functional activity of mouse anti-Pfs230 antibodies judged by a standard membrane-feeding assay with Plasmodium falciparum.

Kazutoyo Miura,Bingbing Deng,Yimin Wu,Luwen Zhou,Thao P Pham,Ababacar Diouf,Chia-Kuei Wu,Shwu-Maan Lee,Jordan L Plieskatt,Merribeth J Morin,Carole A Long

Vaccine（2019）

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摘要

•Multiple mouse anti-Pfs230 antibodies were generated for ELISA and SMFA tests.•There was a significant correlation between ELISA titer and SMFA activity.•However, ELISA titer alone was a poor predictor of functional activity.•Both IgG2/IgG1 ratio and avidity significantly affected functional activity.

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关键词

Plasmodium falciparum,Pfs230,Transmission-blocking vaccine,Standard membrane-feeding assay,IgG subclass,Avidity

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