Effect of supplementary vitamin administration on free amino acids in the liver and brain of rats with alcoholic intoxication]

The authors studied combined action of ethanol, pyridoxine (3 mg/kg), and a mixture of thiamine (5 mg/kg), riboflavin (5 mg/kg), pyridoxine (3 mg/kg) and pantothenate (15 mg/kg) on the free amino acid reserve in the tissues of rats. Ethanol was given to the animals with a liquid semisynthetic diet (its calorific value comprised 36%) during 30 days. Both pyridoxine and the complex of vitamin B group produce normalizing action on the free amino acid pool by correcting the shifts induced by ethanol. It is especially manifested in the decreased levels of urea, isoleucine and GABA in the brain. The data obtained have shown that prevention with vitamins of shifts in the amino acid metabolism induced by ethanol, especially in respect to the central nervous system, should be recommended.