N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
Nature Structural & Molecular Biology（2016）
摘要
BoNT/A1 invades motoneurons by binding to the neuronal receptor SV2. A combination of structural, biophysical and cellular analyses reveal that BoNT/A1 binding and uptake require glycosylation of SV2.
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关键词
Glycoproteins,Glycosylation,Pathogens,X-ray crystallography,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy
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