Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier
Current Opinion in Immunology(2016)
Abstract
•An intact lung barrier is essential to prevent allergic diseases and/or asthma.•Environmental exposures like air pollution and pathogens impair lung barrier function.•Microbe-rich exposures at farms favor a tight barrier and local immunity.•Airway and gut microbiome can influence immunity and barrier function in the lung.•Diet rich in fibers, indigestible carbohydrates or omega-3/6, influences lung immunity.
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