白头翁汤对炎症性肠病中促炎细胞因子表达的影响
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology(2011)
Abstract
目的:探讨白头翁汤治疗炎症性肠病的分子机制。方法:40只Wistar雄性大鼠随机分为5组(n=8):正常对照组、模型组、模型+阳性药物对照组(美沙拉嗪)、模型+白头翁中、高剂量治疗组。阳性对照组、中药治疗组分别灌胃给药。疗程结束后取大鼠结肠组织提取RNA,利用real time PCR的方法检测白介素-1β(IL-1β)、白介素-6(IL-6)及肿瘤坏死因子-α(TNFα-)在各组中的表达变化。结果:相对于模型组,阳性药物及白头翁汤治疗组尤其是高剂量组可有效抑制IL-1β、IL-6及TNFα-的表达。结论:白头翁汤可通过抑制促炎因子的表达从而发挥了在炎症性肠病中的治疗作用。
MoreTranslated text
Key words
pulsatilla decoction,inflammatory bowel disease,proinflammatory cytokines
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined