Intravenous immunoglobulin replacement treatment does not alter polymorphonuclear leukocytes function and surface receptors expression in patients with common variable immunodeficiency

Cellular Immunology(2016)

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摘要
•PMN from HD and CVID show a similar CD11b, CD16 and Siglec 9 surface expression.•PMN from CVID patients show an increased PMA-induced oxidative burst than HD.•IVIg reduced the PMA-induced oxidative burst but not the expression of receptors.•IVIg did not affect the PMN ability to respond to stimulations through Fcγ receptors.
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关键词
CVID,IVIg,HD,MFI,PAD,Siglec 9,ROS,PMN,PMA
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