Multiple-functionalizations of terminal alkynes with sodium sulfinates and tert-butyl nitrite: facile synthesis of 2H-azirines.
CHEMICAL COMMUNICATIONS(2019)
Abstract
A new, catalyst-free tandem annulation route to 2,2-disulfonyl-2H-azirines via multiple-functionalizations of terminal alkynes with sodium sulfinates and tert-butyl nitrite is described. The use of sodium sulfinates and tert-butyl nitrite enables the formation of sulfonyl and NO radicals to selectively initiate and terminate the tandem annulation protocol, constituting a straightforward, conceptually different method to existing 2H-azirine synthesis techniques that currently require multiple steps by prior activation of the common starting materials.
MoreTranslated text
Key words
sodium sulfinates,terminal alkynes,facile synthesis,multiple-functionalizations
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined