Churg-Strauss Syndrome: Singulair Or Silicone (Or Both?)

l eukotriene receptor antagonists have been used successfully for asthma treatment. These drugs could induce eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome (CSS), in patients who are prone to develop autoimmune diseases [1] One of the most important adjuvants responsible for developing ASIA (autoimmune/ inflammatory syndrome induced by adjuvants) is silicone. Patients with silicone-induced ASIA may develop CSS [2-4]. We present two asthmatic female patients diagnosed with CSS who had been exposed to both risk factors: montelukast and silicone. We discuss here how these risk factors could be associated with the development of CSS.