An alternative route to the arylvinyltriazole nucleosides

Mikhail V. Chudinov,Alexander N. Prutkov,Andrey V. Matveev,Lyubov E. Grebenkina,Irina D. Konstantinova,Yulia V. Berezovskaya

Bioorganic & Medicinal Chemistry Letters（2016）

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摘要

A new pathway to synthesis of arylvinyl ribavirin analogues is developed which makes it possible to obtain not only trans- but also cis-isomers at vinyl bond. By this route eight ribavirin 5-arylvinyl analogues are synthesized and their antiviral activity is evaluated.

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关键词

Triazole nucleosides,Nucleoside analogues,HCV

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