IGF-1对精原细胞MAPK途径信号转导的影响

SHEN Guo-Qiu,LU Gong-Cheng,PAN Tie-Jun,XIAO Ya-Jun

Journal of the Fourth Military Medical University（2009）

Cited 23|Views8

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Abstract

目的:研究胰岛素样生长因子1(IGF-1)对大鼠精原细胞MAPK途径分子Erk1和2磷酸化的影响作用.方法:分离并培养大鼠精原细胞,采用不同浓度的IGF-1刺激培养的精原细胞.采用Western Blot方法检测Erk1/2分子的磷酸化.结果:成功获得体外培养的精原细胞,IGF-1刺激后精原细胞Erk1/2分子的磷酸化水平显著增强.IGF-1浓度与Erk1/2磷酸化水平呈正相关关系.结论:IGF-1增强Erk1/2分子的磷酸化水平可能是IGF-1促进精原细胞增殖和提高大鼠生精能力的重要分子机制.

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Key words

spermatogenous cells,phosphorylation,IGF-1

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