盐酸曲唑酮与阿普唑仑治疗成人广泛性焦虑效果比较的Meta分析
Chinese Journal of Evidence-Based Medicine(2013)
Abstract
目的系统评价盐酸曲唑酮与阿普唑仑治疗成人广泛性焦虑的有效性及安全性。方法计算机检索PubMed(1980~2012.5)、CBM(1990~2012.5)、VIP(1989~2012.5)、CNKI(1990~2012.5)和Wanfang Data(1990~2012.5),收集盐酸曲唑酮与阿普唑仑治疗成人广泛性焦虑的随机对照试验,由两名评价者按照纳入与排除标准选择试验、提取资料和评价质量后,采用RevMan 5.0软件进行Meta分析。结果纳入5个RCT,共403例广泛性焦虑症患者。Meta分析结果显示:①治疗4周后,盐酸曲唑酮组与阿普唑仑组的HAMA评分和治愈率的差异无统计学意义[RR=1.04,95%CI(0.95,1.13),P=0.38;RR=1.05,95%CI(0.75,1.48),P=0.76]。②盐酸曲唑酮组的嗜睡发生率低于阿普唑仑组[RR=0.42,95%C(I0.25,0.72),P=0.001],但两组在头晕、乏力、食欲减退发生率方面,差异无统计学意义[RR=0.52,95%C(I 0.27,1.01),P=0.05;RR=0.10,95%C(I 0.01,1.41),P=0.09;RR=2.82,95%C(I 0.28,28.23),P=0.38]。结论盐酸曲唑酮和阿普唑仑治疗广泛性焦虑的疗效无差异,但盐酸曲唑酮不良反应较少,而阿普唑仑更易引起嗜睡。由于纳入研究数量有限且方法学质量不高,本研究结果尚需更多高质量随机对照试验进一步证实。
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Key words
Alprazolam,Generalized anxiety disorder,Meta-analysis,Randomized controlled trial,Systematic review,Trazodone
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