Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice.

Takatoshi Hikida,Makiko Morita,Mahomi Kuroiwa,Tom Macpherson,Takahide Shuto,Naoki Sotogaku,Minae Niwa,Akira Sawa,Akinori Nishi

Neuroscience Research（2020）

引用 7|浏览29

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摘要

•Behavioral sensitization to cocaine was enhanced by GXE.•PDE4 activity was increased in the nucleus accumbens of GXE mice.•Effects of rolipram on the phophrylation of DARPP-32 and GluA1 was enhanced by GXE.•Rolipram inhibited enhanced behavioral sensitization to cocaine in GXE mice.

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关键词

cAMP,CPP,DARPP-32,DISC1-DN,GXE,NAc,PDE4,PFC,PKA,VTA

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