HIF-1基因转染骨髓间充质干细胞治疗SCII的展望
Progress in Modern Biomedicine（2010）
Abstract
脊髓缺血再灌注损伤(spinal cord ischemia-reperfusion injury,SCII)作为原发性脊髓损伤后的继发性损害是造成神经细胞损伤的一个重要因素,目前基因和细胞移植治疗SCII尚处于探索阶段。低氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)产生并处于缺氧应答的关键环节,在缺血后细胞凋亡及微循环的重建等方面起关键作用,用其转染骨髓间充质干细胞(mesenchymal stem cells,MSCs)进行细胞移植治疗SCII,可有望取得新的突破。
MoreTranslated text
Key words
Mesenchymal stem cells,Spinal cord,Hypoxia-inducible factor-1
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined