The clinical application of TGAb and TMAb quantitive determination with enzyme immunoassay in the diagnosis of autoimmune thyroiditis

Objective To explore the clinical application of thyroglobulin antibody(TGAb)and thyroid microsomal antibody(TMAb)quantitive determination with enzyme immunoassay(EIA)in the diagnosis of autoimmune thyroiditis.Methods EIA was applied to quantitively determining serum TGAb and TMAb in 219 patients with thyromegaly(thyromegaly group)and 500 healthy controls (healthy control group).Results The serum level of TGAb and TMAb in thyromegaly group was (295±648)IU/mL[detection rate:61%(134/219)]and(309±536)IU/mL[detection rate:62% (136/219)],respectively.Eventually,126 cases were definitely diagnosed as autoimmune thyroiditis (AITT)through the determination of the two antibodies.The serum level of TGAb and TMAb in healthy control group was(9±4)IU/mL and(14±6)IU/mL respectively.Conclusion TGAb and TMAb quantitive determination with EIA is convenient and accurate,in accordance with clinical requirement, contributing to diagnosis and therapeutic effect evaluation of autoimmune thyroiditis.