TLR9基因多态性与子宫腺肌病的相关性研究
Chinese Preventive Medicine(2013)
Abstract
目的 探讨Toll样受体(Toll-like receptors/TLRs)9基因多态性与子宫腺肌病发病风险的关系.方法 采用DNA直接测序法检测50例子宫腺肌病患者(病例组)和50例对照组的TLR9基因rs352139和rs352140位点的多态性,比较各基因型和等位基因的分布情况.结果 病例组和对照组中,TLR9基因rs352139位点的TT、CT、CC3种基因型频率分别为38%,40%,22%和48%,32%,20%,两组比较差异无统计学意义(x2=1.073,P=0.585);T、C等位基因频率分别58%,42%和64%,36%,两组比较差异无统计学意义(x2 =0.757,P=0.384);TLR9基因rs352140位点的TT、CT、CC3种基因型频率分别为20%,40%,40%和18%,38%,44%,两组比较差异无统计学意义(x2=0.174,P=0.917);T、C等位基因频率分别为40%,60%和37%,63%,两组比较差异无统计学意义(x2=0.190,P=0.663).结论 TLR9基因rs352139和rs352140位点多态性与子宫腺肌病的发病风险无关.
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Key words
Gene polymorphism,Toll-like receptors(TLR)9,Adenomyosis
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