Evaluation of cerebral perfusion in moyamoya diseased patients with posterior cerebral artery lesions by single photon emission tomography examination

Objective: To analyze the abnormal cerebral blood flow perfusion in moyamoya diseased patients with posterior cerebral artery (PCA) lesions. Methods: A total of 27 moyamoya diseased patients with posterior cerebral artery lesions were enrolled in the study. According to the digital subtract angiography (DSA) results, the Suzuki's stages of 27 patients (54 hemispheres) were determined and the PCA grading in all the 27 patients were identified. All the patients accepted single photon emission tomography (SPECT) examination, and the mean value of three or four regions of interest was calculated in five regions (frontal, parietal, temporal, and occipital lobes and basal ganglia). The cerebral-to-cerebellar activity ratio was calculated by dividing the count in these regions by that in the cerebellar hemisphere to assess the rCBF. The effects of the lesion grading of PCA, different Suzuk's grades on rCBF ratio were determined. Results: Circled digit oneWith the increasing of PCA severity, the rCBF in frontal lobe, parietal lobe, temporal lobe, occipital lobe, and basal ganglia decreased gradually. There were significant differences (all P < 0.05). The rCBF ratio value (74 ± 6) of the slight PCA lesions in the parietal lobe was higher than that of moderate lesions (63 ± 9) or severe lesions (60 ± 17). There were significant differences. The rCBF ratio value (72 ± 7) of slight PCA lesions in the occipital lobe was higher than that of the moderate lesions (65 ± 9) and severe lesions (60 ± 15). There were significant differences. Circled digit twoThere were no significant differences in the rCBF ratio comparisons of frontal lobe, parietal lobe, temporal lobe, occipital lobe, and basal ganglia (P > 0.05). Conclusion: The rCBF ratio in each lobe decreases with the severity of PCA lesions, but they are not associated with the severity of the Suzuki's stage. Posterior circulation lesion is an important factor of affecting the cerebral perfusion level in patients with moyamoya disease.