普贝生用于足月羊水偏少引产的临床研究
Strait Pharmaceutical Journal(2009)
Abstract
[目的]观察普贝生用于足月羊水偏少引产的有效性、安全性.[方法]将120例孕37~41周未破膜,合并羊水偏少(B超示羊水指数5.0~8.0 cm)单胎头位产妇随机分为普贝生组和缩宫素组各60例.普贝生组阴道后穹隆放置普贝生引产,缩宫素组常规静滴缩宫素引产,比较普贝生和缩宫素两种药物引产的宫颈Bishop评分、临产时间、分娩情况、阴道分娩率、产后出血、新生儿情况以及不良反应.[结果]普贝生组宫颈评分较宫缩素组显著提高(P<0.01),普贝生组用药到临产时间明显短于缩宫素组(P<0.01),普贝生组引产成功率高于缩宫素组.而产后出血及新生儿窒息率无显著差别.[结论]普贝生用于足月妊娠羊水偏少病例引产安全有效,能显著提高阴道分娩率,降低剖宫产率.
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Key words
oligohydramnios,labor,induced
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