Marine bromophenols as an effective inhibitor of virulent proteins (peptidyl arginine deiminase, gingipain R and hemagglutinin A) in Porphyromas gingivalis.

•The current study aims to investigate the bioactivity of the natural metabolite – Marine bromophenols (MBs) and its properties against the virulent proteins of Porphyromonas gingivalis.•Although marine bromophenols has been studied for their biological activities, this is the first attempt to evaluate its possibility against periodontal pathogen P. gingivalis and its virulent proteins.•A combinatorial approach-in silico molecular modeling and simulation and in vitro antibacterial activity, protein assays and mRNA expression studies are employed in this study to get a better understanding of the bromophenol activity.•By the investigations, it was observed that the bromophenols extracted from red algae Kappaphycus alverizii, controls the growth of P. gingivalis, possibly through the mechanism of inhibiting the activity of virulent proteins both at protein and gene level.