Long-term liraglutide ameliorates nigrostriatal impairment via regulating AMPK/PGC-1a signaling in diabetic mice.

•Liraglutide improved glucose metabolism in adult db/db mice.•Liraglutide ameliorated motor dysfunction of db/db mice.•Liraglutide helped to prevent nigrostriatal impairment in db/db mice.•AMPK/PGC-1a signaling is involved in the neuronal protective effect of liraglutide.