Efficient chemoenzymatic synthesis of UDP-α-6-N3-glucose.

Jiajia Wang, Dongzhe Zhang,Yinhang Wen,Xuefeng Cao,Jing Ma,Peng George Wang

Bioorganic & medicinal chemistry letters（2019）

引用 3|浏览29

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摘要

A novel chemo-enzymatic synthetic method for UDP-α-6-N3-glucose was developed by combining the versatility of chemical synthesis and natural enzyme stereo-selectivity of Bifidobacterium longum (BLUSP). This flexible and efficient platform expanded the substrate scope for UDP-sugars on an improved scale, particularly for UDP-sugar substrates containing bioorthogonal functional groups.

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