EFFECTS OF LIRAGLUTIDE ON RENAL LIPID DEPOSITION OF OBESE RATS

Objective:To study the effects of liraglutide on renal lipid deposition of obese rats.Methods:32 male Wistar rats were randomly divided into the following 4 groups with 8 rats in each group:normal diet group,obese group,liraglutide intervention group 1 and liraglutide intervention group 2.The obese rats were established by using fat diet and the standard for successful model was ratsu0027 body weight increasing 20%.Then the rats in liraglutide intervention group 1and liraglutide intervention group 2 were given liraglutide in different dose for 2 weeks.The 24-hour proteinuria(MAU),creatinine(Scr),urea nitrogen(BUN) and fee fatty acid(FFA) content in serum,as well as triglyceride(TG),diglyceride(DAG) content in kidney of rats in each group were detected.Results:Compared with rats in normal diet group,the MAU,Scr,BUN,FFA,TG and DAG of rats in obese group increased obviously(P0.05).Compared with rats in obese group,the MAU,Scr,BUN,FFA,TG and DAG of rats in liraglutide intervention group 2 decreased obviously(P0.01,P0.05);only the MAU and FFA of rats in liraglutide intervention group 1 decreased obviously(P0.05).Compared with rats in liraglutide intervention group 1,the MAU,FFA,TG and DAG of rats in liraglutide intervention group 2 decreased obviously(P0.05).Conclusions:Liraglutide can improve obesity related renal injury by alleviating renal lipid deposition.