均匀设计法优选祛斑凝胶剂基质处方
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica（2013）
Abstract
目的:优选祛斑凝胶剂基质处方.方法:采用U6(62 ×3)均匀设计法,以凝胶剂的流变学参数(在室温下的黏度和屈服值、在体表温度下的黏度和屈服值、触变性)为指标,优化凝胶剂成型处方.结果:祛斑凝胶剂基质最佳处方为卡波姆9 401.0g,甘油5 mL,pH 5～6.结论:通过建立凝胶基质质量与凝胶流体学参数回归模型,能直接反应各因素影响作用,为凝胶基质处方的筛选能提供一定的参考依据,采用该方法制备的祛斑凝胶剂均匀细腻,黏度适中,触变性良好.
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Key words
matrix formula,quban gel,rheology,uniform design
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