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苯乙烯对接触工人外周血淋巴细胞双核微核率的影响

Industrial Health and Occupational Diseases(2009)

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Abstract
目的探讨苯乙烯对作业工人的遗传损害。方法以胞质分裂阻滞法微核试验(CB-MNT)对接触苯乙烯作业工人54人及不接触苯乙烯工人25人进行细胞遗传毒性效应研究。结果高浓度接触工人双核淋巴细胞微核率明显增高,且随着工龄的延长,双核淋巴细胞微核发生率有增高的趋势。结论苯乙烯对接触工人有一定的遗传毒性作用,双核淋巴细胞微核可作为苯乙烯遗传损害的敏感的生物标志物。
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Key words
Styrene,Genotoxicity,Lymphocyte,Cytokinesis-blocked micronucleus test(CB-MNT)
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