The efficacy of rphotodynamic therapy combined CO_2 laser in treating patients with urethra and anus condyloma acuinatum

Objectives: To observe the clinical efficacy and safety of patients with urethra,anus condyloma acuinatum( CA) treated with 5- aminolevulinic acid photodynamic( ALA- P DT) therapy combined with CO2 laser. Methods: 69 patients were randomly divided into 3 groups of 23 cases,group A for pure ALA- PDT treatment,group B using pure CO2 laser treatment,ALA- PDT combined CO2 laser for group C. The cure rate,recurrence and adverse reactions were observed. Results: After group A having received treatment for 1- 4 times,13 cases of recurrence,10 cases cured; after the first treatment 100% clear in group B,8 cases of recurrence and 15 cases were cured; in group C,3 cases of recurrence,20 cases were cured. Difference in the cure rates among the 3groups were significant,significant difference between group B and C,and no significant difference between group A and C. Difference in the recurrence rates among the 3 groups were not significant after 1 month of treatment. The recurrence rate of group C 2 month,3 month and 1 year after was significant lower than the other groups,with significant difference. All the three groups showed pain,swelling or ulceration of adverse reactions,but without significant difference. Group A and group C had no scarring and pigment changes; in group B,6 cases had superficial scar and3 cases of pigmentation,which was significantly higher than that in group A and group C. Conclusion: ALA- PDT combined CO2 laser is of significant effect,low recurrence rate,and mild adverse reactions in treating patients with urethra and anus CA,thusly safer and more effective.