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松萝酸滴丸的制备及体外溶出度研究

Ying ZHAO,Dan SONG,Xiu-ying XU,Shan-quan FU,Shu LIU

Journal of Chongqing University of Technology(Natural Science)（2011）

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Abstract
为优选松萝酸滴丸剂的制备工艺,考察其体外溶出度.采用均匀设计法,以圆整度、重量差异为指标,对滴丸的制备工艺条件进行优选;采用反相高效液相色谱法测定含量,考察松萝酸滴丸的体外溶出度.结果表明,滴丸的最佳制备工艺条件为:药物与基质配比为3%,PEG(6 000:4 000)为0:100,料温为70℃,滴距为3 cm,体外溶出度良好.该方法简便可行,结果可靠,适用于实验室小量制备和放大生产,体外溶出度符合<中国药典>要求.
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