Effects of Clonazepam Serum Concentrations on Dosage,Pharmacodynamics and ADR in Sleep Disorder Patients

OBJECTIVE To investigate the effect of clonazepam concentration on drug doses,clinical effects and side effects in sleep disorder patients.To confirm the effective concentration range in sleep disorder patients treated by clonazepam. METHODS 66 patients with sleep disorders were treated with clonazepam. Clonazepam serum concentrations was determined by HPLC method. Therapeutic efficacy was measured by PSQI and side effect was rated by TESS.The effect of clonazepam serum concentrations on drug doses,clinical effects and side effects was analyzed statistically.RESULTS A significant positive correlation was found between clonazepam serum concentrations and drug doses(r=0.783, P0.01, n=66).Clonazepam serum concentrations were significant positive correlated with clinical effects(r=0.587,P0.01, n=66).Clonazepam serum concentrations were significant positive correlated with side effects(r=0.654,P0.01, n=66).CONCLUSION Clonazepam serum concentrations are significant positive correlated with drug doses, Clonazepam serum concentrations are significant positive correlated with clinical effects,clonazepam serum concentrations are significant positive correlated with side effects.The optimal serum concentrations of clonazepam is 16～35 μg·L -1 . The results indicate that monitoring clonazepam concentration have the clinical significance for using the drug reasonably.