Both N- and C-terminal domains of galectin-9 are capable of inducing HIV reactivation despite mediating differential immunomodulatory functionalities.

Ashwini Shete, Mahalakshmi Bhat,Jyoti Sawant,Supriya Deshpande

Frontiers in immunology（2022）

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摘要

N- and C-CRDs were found to induce HIV reactivation similar to that of the full-length protein, indicating their possible usefulness in the shock-and-kill strategy. The study indicated an anti-inflammatory role of N-CRD versus the proinflammatory properties of C-CRD of galectin-9 in HIV infection.

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关键词

HIV,N- and C-terminal binding domains,galectin-9,immunomodulation,reactivation

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