An Opsonophagocytic Assay to Evaluate Immunogenicity of Non-Typhoidal Salmonella Vaccines.

Girish Ramachandran,Mary Adetinuke Boyd, Jennifer MacSwords,Ellen E Higginson,Raphael Simon,James E Galen,Marcela F Pasetti,Myron M Levine,Sharon M Tennant

CLINICAL AND VACCINE IMMUNOLOGY（2016）

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摘要

Nontyphoidal Salmonella (NTS) invasive infections are an important cause of morbidity and mortality in sub-Saharan Africa. Several vaccines are in development to prevent these infections. We describe an NTS opsonophagocytic killing assay that uses HL-60 cells and baby rabbit complement to quantify functional antibodies elicited by candidate NTS vaccines.

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