An ROS-responsive and self-accelerating drug release nanoplatform for overcoming multidrug resistance.

An 'on-demand' drug release and ROS-responsive nanoparticle was prepared by chemically conjugating hydrophobic alpha-tocopheryl succinate to hydrophilic poly(ethylene glycol) via a thioketal linker. This nanoparticle encapsulated with doxorubicin and alpha-tocopheryl succinate exhibited remarkable efficiency in reversing multidrug resistance both in vitro and in vivo.