Immunogenicity and safety of two doses of catch-up immunization with Haemophilus influenzae type b conjugate vaccine in Indian children living with HIV

•The optimal schedule for HibCV in children with HIV is unclear in settings with limited access to ART.•The recommended schedule of 1 dose of HibCV may be inadequate in such settings.•76% of HIV infected children 2–15 years mounted an immune response following 2-doses of HibCV.•Immune responses were adequate even among children with viral loads >100,000copies/mL.•Anti-Hib-PRP IgG≥3.3μg/mL provided protection against Hib NP colonization in children with HIV.