Decreased Level of IgE is Associated with Breast Cancer and Allergic Diseases.

Background: The aim of this study was to explore the prevalence of type I allergic diseases in patients with breast cancer by carrying out a questionnaire survey and IgE detection in a healthy population and in patients with breast cancer. Material/Method: There were 309 patients enrolled and they were further divided into the type I allergic disease group, the newly diagnosed breast cancer with type I allergic disease group, the re-visit breast cancer with type I allergic disease group, and the re-visit breast cancer without type I allergic disease group, as well as a healthy control group. Serum total IgE level was detected by immunoassay. Results: The IgE value in the healthy population with type I allergic diseases (89.3 +/- 51.4 IU/ml) was significantly higher than in those without type I allergic diseases (45.6 +/- 65.1 IU/ml). There was no significant difference between IgE values in the re-visit breast cancer patients with type I allergic disease (25.1 +/- 65.1 IU/ml) and those without type I allergic disease (23.0 +/- 45.9 IU/ml). The area under the ROC curve was 0.618 +/- 0.04, sensitivity was 78%, specificity was 47.1%, Youden index was 0.251, and IgE threshold was 32.6 IU/ml. Conclusions: The patients with newly diagnosed breast cancer were susceptible to type I allergic disease at about the same levels as in the healthy population. There was no correlation between breast cancer and type I allergic disease.