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Systemic growth hormone deficiency causes mechanical and thermal hypersensitivity during early postnatal development.

Zachary K Ford,Adam J Dourson,Xiaohua Liu,Peilin Lu,Kathryn J Green,Renita C Hudgins,Michael P Jankowski

IBRO Reports（2019）

Cited 6|Views17
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Abstract
•Systemic GHD causes behavioral hypersensitivity at P7 and P14, but not P21.•Primary afferent sensitization is observed in GHRHr KOs.•Knockout of GHRHr changes DRG gene expression that is observed throughout development.
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Key words
Neonatal,Dorsal root ganglion,Pain,Electrophysiology,Molecular biology,Growth hormone
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