Identification of Substituted Naphthotriazolediones As Novel Tryptophan 2,3-Dioxygenase (tdo) Inhibitors Through Structure-Based Virtual Screening
Journal of medicinal chemistry(2015)
Abstract
A structure-based virtual screening strategy, comprising homology modeling, ligand support binding site optimization, virtual screening, and structure clustering analysis, was developed and used to identify novel tryptophan 2,3-dioxygenase (TDO) inhibitors. Compound 1 (IC50 = 711 nM), selected by virtual screening, showed inhibitory activity toward TDO and was subjected to structural modifications and molecular docking studies. This resulted in the identification of a potent TDO selective inhibitor (11e, IC50 = 30 nM), making it a potential compound for further investigation as a cancer therapeutic and other TDO-related targeted therapy.
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