Characterization of in vitro metabolism of focal adhesion kinase inhibitors by LC/MS/MS.

Journal of Pharmaceutical and Biomedical Analysis（2019）

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摘要

•The in vitro metabolites of FAK inhibitors were analyzed by LC/MS/MS.•The structures and fragmentation patterns were characterized.•Typical metabolic pathways include hydroxylation, dehydrogenation and N-dealkylation.

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关键词

Focal adhesion kinase inhibitor,Metabolites,LC/MS/MS,Metabolic pathway

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