Overexpression of carbamoyl-phosphate synthase 1 significantly improves ureagenesis of human liver HepaRG cells only when cultured under shaking conditions.

Aziza A A Adam,Vincent A van der Mark,Jos P N Ruiter,Ronald J A Wanders,Ronald P J Oude Elferink,Robert A F M Chamuleau,Ruurdtje Hoekstra

Mitochondrion（2019）

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摘要

Hyperammonemia is an important contributing factor to hepatic encephalopathy in end-stage liver failure patients. Therefore reducing hyperammonemia is a requisite of bioartificial liver support (BAL).

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关键词

Bioartificial liver,Urea cycle,Transduction,Mitochondria,Carbamoyl-phosphate synthase1

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